Soy Phytoestrogens on DNA Methylation in Prostate Cancer
نویسندگان
چکیده
Citation: Daures M, Ngollo M, Idrissou M, et al. Soy Phytoestrogens on DNA Methylation in Prostate Cancer. J Clin Epigenet. 2017, 3:1. Soy phytoestrogens are dietary components with considerable effects on reducing the incidence of prostate cancer. Furthermore, the epigenetic regulation of gene expression can be modified by soy phytoestrogens [1]. Qualitative and quantitative studies show a decrease of promoter methylation on tumour suppressor gene such as BRCA1, BRCA2, EPHB2, GSTP1 and RASSF1A on prostate cancer cell lines treated with genistein and daidzein. Effects of both molecules were compared to the demethylating agent of DNA, the 5-azacytidin [2,3]. Indeed, these genes are known to be hypermethylated in prostate cancer. This hypermethylation leads to the loss of their expressions and to chemotherapy-resistance of tumor cells [4,5].
منابع مشابه
Soy phytoestrogens modify DNA methylation of GSTP1, RASSF1A, EPH2 and BRCA1 promoter in prostate cancer cells.
BACKGROUND The aim of this study was to determine the effects of soy phytoestrogens on the methylation of promoter genes in prostate tumors. The incidence of prostate cancer in Asia is thirty percent lower than in Western countries. Since soy phytoestrogens represent a large portion of the Asian diet, evidence suggests their protective effect against prostate cancer. MATERIALS AND METHODS In ...
متن کاملPhytoestrogens are partial estrogen agonists in the adult male mouse.
The intake, as well as serum and urinary concentrations, of phytoestrogens is high in countries where incidence of prostate cancer is low, suggesting a chemopreventive role for phytoestrogens. Their significance could be explained by the ability to antagonize the action of more potent endogenous estrogens in initiation or promotion of tumor formation. We have studied estrogenicity and antiestro...
متن کاملPhytoestrogens and Breast Cancer
Numerous epidemiological studies suggest that diets rich in phytoestrogens (PE), particularly soy and unrefined grain products, may be associated with low risk of some cancers, especially steroid hormone-dependent, e.g. breast and prostate cancers. Epidemiological, in vitro, animal and human studies have investigated the mechanisms involved in PE biological actions, including steroid hormone ac...
متن کاملImpact of Soy Isoflavones on the Epigenome in Cancer Prevention
Isoflavones (IF) such as genistein are cancer preventive phytochemicals found in soy and other legumes. Epidemiological studies point to a reduced risk for hormone‑dependent cancers in populations following a typical Asian diet rich in soy products. IF act as phytoestrogens and prevent tumorigenesis in rodent models by a broad spectrum of bioactivities. During the past 10 years, IF were shown t...
متن کاملEffects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer.
OBJECTIVES To determine the effects of diets rich in soy and linseed compared with a control diet on biochemical markers of prostate cancer in men diagnosed with prostate cancer. METHODS Twenty-nine men diagnosed with prostate cancer and scheduled to undergo a radical prostatectomy were randomized to one of three groups: soy (high phytoestrogen), soy and linseed (high phytoestrogen), or wheat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017